Researchers from the Indian Institute of Technology, Bombay (IIT B) have taken the first successful step at regenerating neurons in a Parkinson mouse model by using mesenchymal stem cells (MSCs) encapsulated in an amyloid hydrogel. The hydrogels which provide scaffolding for stem cells to develop into neurons when implanted in the brain are developed from a special class of proteins called amyloids. The results were published in the journal NPG Asia Materials.
The hydrogel enabled the delivery and engraftment of mesenchymal stem cells in two regions of the mice brain – substantia nigra and striatum – where the cells were injected. “We do not have direct proof that mesenchymal stem cells have become neurons. But the stem cells transplanted at the substantia nigra site were differentiating into neuron-like cells,” says Subhadeep Das from IITB-Monash Research Academy, IIT Bombay and the first author of the paper.
“We wanted to first know…
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